Document Type
Poster
Publication Date
8-1-2008
Abstract
Activating mutations in SHP-2 tyrosine phosphatase implicated in cell signaling processes have been identified in various childhood leukemias and sporadic solid tumors. However, the molecular mechanisms by which the activating mutations in SHP-2 induce malignancies are not fully understood. In this study, we investigated potential involvement of SHP-2 in chromosome segregation during mitosis, dysregulation of which leads to genome instability and malignancies. We determined localization of SHP-2 in the kinetochore, a crucial protein complex structure connecting microtubules and chromosomes. We found that SHP-2 localized at the kinetochore. Our findings suggest that SHP-2 may be involved in chromosome segregation and can help to answer how SHP-2 mutations can induce genetic instability and thereby malignancies.
Keywords
PTPN11 protein--human, protein tyrosine is phosphatase--non-receptor type 11, kinetochores
Publication Title
Intersections Source Symposium 2008
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Recommended Citation
Cintron, D., Liu, X., & Qu, C.K. (2008). Localization of SHP-2 Phosphatase to the Kinetochore. Intersections Source Symposium 2008.