Author ORCID Identifier
Document Type
Article
Publication Date
6-8-2018
Abstract
Objective: To assess expert consensus on barriers and facilitators for long-acting injectable antipsychotic (LAI) use and provide clinical recommendations on issues where clinical evidence is lacking, including identifying appropriate clinical situations for LAI use. Methods: A 50-question survey comprising 916 response options was distributed to 42 research experts and high prescribers with extensive LAI experience. Respondents rated options on relative appropriateness/importance using a 9-point scale. Consensus was determined using chi-square test of score distributions. Mean (standard deviation) ratings were calculated. Responses to 29 questions (577 options) relating to appropriate patients and clinical scenarios for LAI use are reported. Results: Recommendations aligned with research on risk factors for nonadherence and poor outcomes for patients with schizophrenia/schizoaffective or bipolar disorder. Findings suggested, contrary to general practice patterns, that LAI use may be appropriate earlier in the disease course and in younger patients. Results for bipolar disorder were similar to those for schizophrenia but with less consensus. Numerous facilitators of LAI prescribing were considered important, particularly that LAIs may reduce relapses and improve outcomes. Conclusion: Findings support wider use of LAIs in patients with schizophrenia/schizoaffective and bipolar disorders beyond the setting of poor adherence and earlier use in the disease course.
Keywords
bipolar disorder, expert consensus, long-acting injectable antipsychotics, schizoaffective disorder, schizophrenia
Language
English
Publication Title
Neuropsychiatric Disease and Treatment
Rights
© The Author(s)2018. This is an open access work distributed under the terms of the Creative Commons Attribution-Non-Commercial (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Recommended Citation
Kaddumukasa M, Katabira E, Salata RA, Costa MA, Ddumba E, Furlan A, Kakooza-Mwesige A, Kamya MR, Kayima J, Longenecker CT, Mayanja-Kizza H, Mondo C, Moore S, Pundik S, Sewankambo N, Simon DI, Smyth KA, Sajatovic M. Global medical education partnerships to expand specialty expertise: a case report on building neurology clinical and research capacity. Hum Resour Health. 2014 Dec 30;12:75. doi: 10.1186/1478-4491-12-75. PMID: 25547168; PMCID: PMC4531526.
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