Document Type
Article
Publication Date
6-7-2016
Abstract
It has previously demonstrated that cholesterol efflux from the cell plasma membrane is increased in a mouse model of cystic fibrosis (CF) compared to a wild-type control. A noninvasive means of characterizing plasma membrane cholesterol efflux at the surface of airway tissue of CF patients is needed to extend the trends found in animal models of CF to the human disease state. Microelectrode-induced cholesterol efflux from the plasma membrane of cells at the surface of tissue is proposed as a strategy to demonstrate increased cholesterol efflux for CF in human subjects. Data demonstrating detection of cholesterol efflux from the human buccal mucosa is reported as proof-of-concept for an in vivo diagnostic assay.
Language
English
Publication Title
Journal of the Electrochemical Society
Rights
© The Author(s) 2016. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/), which permits non-commercial copying and redistribution of the material in any medium or format, provided the original work is not changed in any way and is properly cited.
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Recommended Citation
Yu X, Kelley TJ, Chiel HJ, Burgess JD. Communication-Microelectrode Detection of Cholesterol Efflux from the Human Buccel Mucosa. J Electrochem Soc. 2016;163(8):B453-B455. doi: 10.1149/2.1001608jes. Epub 2016 Jun 7. PMID: 27546897; PMCID: PMC4988675.
Manuscript Version
Final Publisher Version