Document Type
Article
Publication Date
7-28-2014
Abstract
Nerve block can eliminate spasms and chronic pain. Kilohertz frequency alternating current (KHFAC) produces a safe and reversible nerve block. However, KHFAC-induced nerve block is associated with an undesirable onset response. Optical inhibition using infrared (IR) laser light can produce nerve block without an onset response, but heats nerves. Combining KHFAC with IR inhibition [alternating current and infrared (ACIR)] produces a rapidly reversible nerve block without an onset response. ACIR can be used to rapidly and reversibly provide onset-free nerve block in the unmyelinated nerves of the marine mollusk Aplysia californica and may have significant advantages over either modality alone. ACIR may be of great clinical utility in the future.
Keywords
Aplysia, high-frequency alternating current, infrared laser light, nerve block, optical inhibition, pain, spasm
Language
English
Publication Title
Neurophotonics
Grant
R01-NS-074149
Rights
©2014 The Author(s). This is an Open Access work distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Emilie H. Lothet, Kevin L. Kilgore, Niloy Bhadra, Narendra Bhadra, Tina Vrabec, Yves T. Wang, E. Duco Jansen, Michael W. Jenkins, Hillel J. Chiel, "Alternating current and infrared produce an onset-free reversible nerve block," Neurophoton. 1(1) 011010 (28 July 2014) https://doi.org/10.1117/1.NPh.1.1.011010
Manuscript Version
Final Publisher Version