Document Type
Article
Publication Date
8-23-2024
Abstract
In this study, guest carriers, composed of magnetic-directed hydrogel particles with near-infrared (NIR)-light-triggered guest-release properties, are prepared via the one-pot method. The gel particles contain photostable NIR-responsive polypyrrole nanoparticles with temperature-sensitive poly(N-isopropyl acrylamide), the combination of which can induce the accelerated release of encapsulated drugs by 337% upon 5 minutes of NIR light irradiation based on the release profile of NRMG-1 at 10–15 min. Additionally, with magnetic iron oxide particles crosslinking the polyvinyl alcohol frames, these gel particles can form a physical barrier that decreases the release rate by 20% under an external magnetic field over 24 h. The magnetic iron oxide particles also enable the gel particles to reach their target destination without extra drug losses.
Keywords
biocompatibility, biomedical applications, drug delivery systems
Language
English
Publication Title
Journal of Applied Polymer Science
Rights
© 2024 The Author(s). This is an Open Access work distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
J. Ge, X. Cheng, L. Rong, P.-F. Cao, E. B. Caldona, R. Advincula, J. Appl. Polym. Sci. 2024, 141(42), e56110. https://doi.org/10.1002/app.56110
Manuscript Version
Final Publisher Version