Document Type
Article
Publication Date
1-8-2025
Abstract
Objectives: To evaluate cariprazine in adults with older- and younger-age bipolar I disorder (OABD-I and YABD-I) and compare treatment effects between them. Design and setting: Pooled post-hoc analysis of studies in depressive or acute manic/mixed episodes associated with bipolar I disorder. Participants: 475/1383 patients (34.3%) in 3 depression trials and 238/1037 patients (23.0%) in 3 manic/mixed trials were OABD-I. Interventions: Depression: placebo, cariprazine 1.5 mg/day, 3.0 mg/day, pooled 1.5-3.0 mg/day. Manic/mixed: placebo, cariprazine 3.0-6.0 mg/day, and 9.0-12.0 mg/day. Measurements: Montgomery-Åsberg Depression Rating Scale (MADRS), Clinical Global Impression of Severity (CGI-S), and Young Mania Rating Scale (YMRS). Results: In bipolar I depression, mean change from baseline in MADRS was significantly greater for the pooled cariprazine group vs. placebo in OABD-I (−13.72 vs. −11.98; p < 0.05) and for each cariprazine group vs. placebo among YABD-I. There was no significant difference in treatment effect between OABD-I and YABD-I for either individual cariprazine group vs. placebo. For mania/mixed states, mean change in YMRS was significantly greater for cariprazine 3.0-6.0 mg/day vs. placebo in OABD-I (−19.04 vs. −12.45; p < 0.001) and for both cariprazine groups in YABD-I (−12.49, −19.66 and −18.05 for placebo, cariprazine 3.0–6.0 mg/day and 9.0–12.0 mg/day, respectively [both p < 0.0001 vs. placebo]). There was no significant difference in treatment effect between OABD-I and YABD-I for cariprazine 3.0–6.0 mg/day vs. placebo; there was a significantly higher treatment effect for cariprazine 9.0–12.0 mg/day vs. placebo in the YABD-I subpopulation vs. OABD-I (4.20; p < 0.05). Conclusions: Cariprazine appears to be effective for both depressive and manic/mixed episodes of bipolar I disorder, regardless of age.
Keywords
bipolar depression, bipolar mania, Cariprazine, older age bipolar disorder
Language
English
Publication Title
American Journal of Geriatric Psychiatry
Rights
© 2025 TheAuthors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/), which permits non-commercial copying and redistribution of the material in any medium or format, provided the original work is not changed in any way and is properly cited.
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Recommended Citation
Garel, N., Dols, A., Yu, J., Di Cresce, C., Rej, S., & Sajatovic, M. (2025). Effect of cariprazine on outcomes in older-aged and younger-aged patients with bipolar I disorder: a post-hoc analysis. The American Journal of Geriatric Psychiatry, 33(4), 372-386. https://doi.org/10.1016/j.jagp.2024.12.006
Manuscript Version
Final Publisher Version