Author ORCID Identifier

Robert W. Maitta

Document Type

Article

Publication Date

8-1-2023

Abstract

Collections of lymphocytes to be genetically modified to treat hematologic malignancies have seen a dramatic increase over the last few years as commercial products have been approved. Reports of new products in development that can possibly treat solid organ malignancies represent a massive change in the field. Apheresis is at the center of the collection of cells for the manufacture of these chimeric-antigen receptor therapy products. The expansion of these collections represents one of the areas of apheresis procedures growth. This review will summarize concepts important to this type of collection and variables that need to be optimized to obtain desired cell yields while increasing patients' safety.

Keywords

adverse events, apheresis, CAR T, cell collections, chimeric-antigen receptor therapy, efficiency, variables

Publication Title

European Journal of Haematology

Rights

© 2023 The Author

Creative Commons License

Creative Commons Attribution-NonCommercial 4.0 International License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License

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