Heterogeneous Red Blood Cell Adhesion and Deformability in Sickle Cell Disease

Authors

Yunus Alapan, Case Western Reserve University
Jane A. Little, Case Western Reserve UniversityFollow
Umut A. Gurkan, Case Western Reserve UniversityFollow

Author ORCID Identifier

Yunus Alapan

Umut A. Gurkan

Document Type

Article

Publication Date

7-17-2014

DOI

10.1038/srep07173

Abstract

We present a microfluidic approach that allows simultaneous interrogation of RBC properties in physiological flow conditions at a single cell level. With this method, we studied healthy hemoglobin A (HbA) and homozygous sickle hemoglobin (HbS) containing RBCs using whole blood samples from twelve subjects. We report that HbS-containing RBCs are heterogeneous in terms of adhesion and deformability in flow.

Publication Title

Scientific Reports

Volume

4

Grant

2013126

Funder

Doris Duke Charitable Foundation Innovations in Clinical Research Award

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.

Recommended Citation

Alapan, Yunus; Little, Jane A.; and Gurkan, Umut A., "Heterogeneous Red Blood Cell Adhesion and Deformability in Sickle Cell Disease" (2014). Faculty Scholarship. 31.
https://commons.case.edu/facultyworks/31