Document Type
Article
Publication Date
7-17-2014
Abstract
We present a microfluidic approach that allows simultaneous interrogation of RBC properties in physiological flow conditions at a single cell level. With this method, we studied healthy hemoglobin A (HbA) and homozygous sickle hemoglobin (HbS) containing RBCs using whole blood samples from twelve subjects. We report that HbS-containing RBCs are heterogeneous in terms of adhesion and deformability in flow.
Publication Title
Scientific Reports
Grant
2013126
Funder
Doris Duke Charitable Foundation Innovations in Clinical Research Award
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Recommended Citation
Alapan, Yunus; Little, Jane A.; and Gurkan, Umut A., "Heterogeneous Red Blood Cell Adhesion and Deformability in Sickle Cell Disease" (2014). Faculty Scholarship. 31.
https://commons.case.edu/facultyworks/31