We present a microfluidic approach that allows simultaneous interrogation of RBC properties in physiological flow conditions at a single cell level. With this method, we studied healthy hemoglobin A (HbA) and homozygous sickle hemoglobin (HbS) containing RBCs using whole blood samples from twelve subjects. We report that HbS-containing RBCs are heterogeneous in terms of adhesion and deformability in flow.
Doris Duke Charitable Foundation Innovations in Clinical Research Award
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Alapan, Yunus; Little, Jane A.; and Gurkan, Umut A., "Heterogeneous Red Blood Cell Adhesion and Deformability in Sickle Cell Disease" (2014). Faculty Scholarship. 31.