Document Type

Article

Publication Date

7-17-2014

DOI

10.1038/srep07173

Publication Title

Scientific Reports

Volume

4

College/School

Case School of Engineering

College/School

School of Medicine

Department/Center

Mechanical & Aerospace Engineering

Grant

2013126

Funder

Doris Duke Charitable Foundation Innovations in Clinical Research Award

Abstract

We present a microfluidic approach that allows simultaneous interrogation of RBC properties in physiological flow conditions at a single cell level. With this method, we studied healthy hemoglobin A (HbA) and homozygous sickle hemoglobin (HbS) containing RBCs using whole blood samples from twelve subjects. We report that HbS-containing RBCs are heterogeneous in terms of adhesion and deformability in flow.

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