Document Type
Article
Publication Date
7-17-2014
Publication Title
Scientific Reports
Volume
4
College/School
Case School of Engineering
College/School
School of Medicine
Grant
2013126
Funder
Doris Duke Charitable Foundation Innovations in Clinical Research Award
Abstract
We present a microfluidic approach that allows simultaneous interrogation of RBC properties in physiological flow conditions at a single cell level. With this method, we studied healthy hemoglobin A (HbA) and homozygous sickle hemoglobin (HbS) containing RBCs using whole blood samples from twelve subjects. We report that HbS-containing RBCs are heterogeneous in terms of adhesion and deformability in flow.
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Recommended Citation
Alapan, Yunus; Little, Jane A.; and Gurkan, Umut A., "Heterogeneous Red Blood Cell Adhesion and Deformability in Sickle Cell Disease" (2014). Faculty Scholarship. 31.
https://commons.case.edu/facultyworks/31