Socioeconomic Deprivation and Cardiometabolic Risk Factors in Individuals with Type 1 Diabetes: T1D Exchange Clinic Registry

Authors

Stephanie Griggs, Case Western Reserve UniversityFollow
Sadeer Al-Kindi, Case Western Reserve UniversityFollow
Heather Hardin, Case Western Reserve University
Elliane Irani, Case Western Reserve UniversityFollow
Sanjay Rajagopalan, Case Western Reserve UniversityFollow
Ronald L. Hickman Jr., Case Western Reserve UniversityFollow

Author ORCID Identifier

Stephanie Griggs

Elliane Irani

Document Type

Article

Publication Date

12-10-2022

Abstract

Aims: Social determinants of health (SDOH) influence cardiovascular health in the general population; however, the degree to which this occurs in individuals with type 1 diabetes (T1D) is not well understood. We evaluated associations among socioeconomic deprivation and cardiometabolic risk factors (hemoglobin A1c, low-density lipoprotein, blood pressure, body mass index, physical activity) in individuals with T1D from the T1D Clinic Exchange Registry. Methods: We evaluated the association between the social deprivation index (SDI) and cardiometabolic risk factors using multivariable and logistic regression among 18,754 participants ages 13 – 90 years (mean 29.2 ± 17) in the T1D Exchange clinic registry from 6,320 zip code tabulation areas (2007–2017). Results: SDI was associated with multiple cardiometabolic risk factors even after adjusting for covariates (age, biological sex, T1D duration, and race/ethnicity) in the multivariable linear regression models. Those in the highest socially deprived areas had 1.69 (unadjusted) and 1.78 (adjusted) times odds of a triple concomitant risk burden of poor glycemia, dyslipidemia, and hypertension. Conclusions: Persistent SDOH differences could account for a substantial degree of poor achievement of cardiometabolic targets in individuals with T1D. Our results suggest the need for a broader framework to understand the association between T1D and adverse cardiometabolic outcomes.

Keywords

cardiometabolic risk, social deprivation, social determinants of health, type 1 diabetes

Publication Title

Diabetes Research and Clinical Practice

Rights

© 2022 Elsevier B.V. All rights reserved.

Comments

This is a peer reviewed Accepted Manuscript of an article published by Elsevier in Diabetes Research and Clinical Practice available at https://doi.org/10.1016/j.diabres.2022.110198.

Recommended Citation

Griggs S, Al-Kindi S, Hardin H, Irani E, Rajagopalan S, Crawford SL, Hickman RL Jr. Socioeconomic deprivation and cardiometabolic risk factors in individuals with type 1 diabetes: T1D exchange clinic registry. Diabetes Res Clin Pract. 2023 Jan;195:110198. doi: 10.1016/j.diabres.2022.110198.