Author ORCID Identifier

Stephanie Griggs

Elliane Irani

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Aims: Social determinants of health (SDOH) influence cardiovascular health in the general population; however, the degree to which this occurs in individuals with type 1 diabetes (T1D) is not well understood. We evaluated associations among socioeconomic deprivation and cardiometabolic risk factors (hemoglobin A1c, low-density lipoprotein, blood pressure, body mass index, physical activity) in individuals with T1D from the T1D Clinic Exchange Registry. Methods: We evaluated the association between the social deprivation index (SDI) and cardiometabolic risk factors using multivariable and logistic regression among 18,754 participants ages 13 – 90 years (mean 29.2 ± 17) in the T1D Exchange clinic registry from 6,320 zip code tabulation areas (2007–2017). Results: SDI was associated with multiple cardiometabolic risk factors even after adjusting for covariates (age, biological sex, T1D duration, and race/ethnicity) in the multivariable linear regression models. Those in the highest socially deprived areas had 1.69 (unadjusted) and 1.78 (adjusted) times odds of a triple concomitant risk burden of poor glycemia, dyslipidemia, and hypertension. Conclusions: Persistent SDOH differences could account for a substantial degree of poor achievement of cardiometabolic targets in individuals with T1D. Our results suggest the need for a broader framework to understand the association between T1D and adverse cardiometabolic outcomes.


cardiometabolic risk, social deprivation, social determinants of health, type 1 diabetes

Publication Title

Diabetes Research and Clinical Practice




© 2022 Elsevier B.V. All rights reserved.


This is a peer reviewed Accepted Manuscript of an article published by Elsevier in Diabetes Research and Clinical Practice available at

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10.1016/j.diabres.2022.110198" data-hide-no-mentions="true">
10.1016/j.diabres.2022.110198" data-hide-zero-citations="true" data-style="small_circle">

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