Author ORCID Identifier
Document Type
Article
Publication Date
8-3-2018
Abstract
Intracortical microelectrodes are used both in basic research to increase our understanding of the nervous system and for rehabilitation purposes through brain-computer interfaces. Yet, challenges exist preventing the widespread clinical use of this technology. A prime challenge is with the neuroinflammatory response to intracortical microelectrodes. This mini-review details immunomodulatory strategies employed to decrease the inflammatory response to these devices. Over time, broad-spectrum anti-inflammatory approaches, such as dexamethasone and minocycline, evolved into more targeted treatments since the underlying biology of the neuroinflammation was elucidated. This review also presents studies which examine novel prospective targets for future immunomodulatory targeting.
Keywords
intracortical microelectrode, brain, anti-inflammatory, brain-machine interface, neuroinflammation, glial response
Publication Title
Journal of Immunological Sciences
Rights
© 2018 Capadona JR.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Bedell HW, Capadona JR. Anti-inflammatory Approaches to Mitigate the Neuroinflammatory Response to Brain-Dwelling Intracortical Microelectrodes. J Immunol Sci. (2018); 2(4): 15-21. https://doi.org/10.29245/2578-3009/2018/4.1157