Author ORCID Identifier
Document Type
Article
Publication Date
12-18-2008
Abstract
With the continuing march of the AIDS epidemic and little hope for an effective vaccine in the near future, work to develop a topical strategy to prevent HIV infection is increasingly important. This stated, the track record of large scale "microbicide" trials has been disappointing with nonspecific inhibitors either failing to protect women from infection or even increasing HIV acquisition. Newer strategies that target directly the elements needed for viral entry into cells have shown promise in non-human primate models of HIV transmission and as these agents have not yet been broadly introduced in regions of highest HIV prevalence, they are particularly attractive for prophylaxis. We review here the agents that can block HIV cellular entry and that show promise as topical strategies or "virustats" to prevent mucosal transmission of HIV infection.
Keywords
bacterial vaginosis, enfuvirtide, dextran sulfate, vaginal microbiota, cellulose sulfate
Language
English
Publication Title
Retrovirology
Rights
© 2008 Lederman et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Recommended Citation
Lederman, M.M., Jump, R., Pilch-Cooper, H.A. et al. Topical application of entry inhibitors as "virustats" to prevent sexual transmission of HIV infection. Retrovirology 5, 116 (2008). https://doi.org/10.1186/1742-4690-5-116
Manuscript Version
Final Publisher Version