Autoimmune Condition Diagnosis Following Recurrent Pregnancy Loss
Document Type
Article
Publication Date
10-26-2024
Abstract
Problem: Research has suggested a link between recurrent pregnancy loss (RPL) and cell-mediated immunity dysregulation. We aimed to determine if a history of RPL is associated with diagnosis of a cell-mediated autoimmune condition (AIC). Method of Study: A retrospective cohort study was conducted using the TriNetX research network. The RPL group had ≥3 spontaneous or missed abortions. Controls had at least one pregnancy but no diagnosis of RPL. Propensity score matching was used for age, race, and ethnicity. Z-test and relative risk analysis investigated the relationship between RPL and subsequent AIC diagnoses. Results: One hundred twenty-eight thousand three hundred seventy-six patients were included in each cohort. RPL was associated with an increased risk for an AIC composite (RR 1.60, 95% CI [1.51, 1.69]), Crohn's disease, Graves’ disease, Hashimoto's thyroiditis, multiple sclerosis, rheumatoid arthritis, Sjogren's syndrome, systemic lupus erythematosus, and ulcerative colitis, but not psoriatic arthritis. Conclusions: Using a large research database of patients with RPL, we were able to demonstrate that an antecedent diagnosis of RPL is associated with increased risk of subsequent diagnosis of an AIC, often between 1 and 10 years after RPL.
Keywords
autoimmune diseases, cellular, immunity, pregnancy, propensity score, retrospective studies
Language
English
Publication Title
American Journal of Reproductive Immunology
Rights
© 2024 The Author(s). American Journal of Reproductive Immunology published by John Wiley & Sons Ltd. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/BY-NC-ND/4.0/), which permits non-commercial copying and redistribution of the material in any medium or format, provided the original work is not changed in any way and is properly cited.
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Recommended Citation
Imbroane, M.R., LeMoine, F. and Gibson, K.S. (2024), Autoimmune Condition Diagnosis Following Recurrent Pregnancy Loss. Am J Reprod Immunol, 92: e70006. https://doi.org/10.1111/aji.70006
Manuscript Version
Final Publisher Version