Document Type
Article
Publication Date
1-23-2024
Abstract
Mendelian randomization (MR) has become a popular tool for inferring causality of risk factors on disease. There are currently over 45 different methods available to perform MR, reflecting this extremely active research area. It would be desirable to have a standard simulation environment to objectively evaluate the existing and future methods. We present simmrd, an open-source software for performing simulations to evaluate the performance of MR methods in a range of scenarios encountered in practice. Researchers can directly modify the simmrd source code so that the research community may arrive at a widely accepted framework for researchers to evaluate the performance of different MR methods.
Keywords
bias, causal inference, instrumental variables, Mendelian randomization, simulation
Language
English
Publication Title
Genetic Epidemiology
Grant
T32 HL007567
Rights
© 2024 The Authors. Genetic Epidemiology published by Wiley Periodicals LLC. This is an Open Access work distributed under the terms of the Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Lorincz-Comi, N., Yang, Y., & Zhu, X. (2024). simmrd: An open-source tool to perform simulations in Mendelian randomization. Genetic Epidemiology, 48, 59–73. https://doi.org/10.1002/gepi.22544
Manuscript Version
Final Publisher Version