Document Type
Article
Publication Date
10-1-2019
Abstract
Thermal block of unmyelinated axons may serve as a modality for control, suggesting a means for providing therapies for pain. Computational modeling predicted that potassium channels are necessary for mediating thermal block of propagating compound action potentials (CAPs) with infrared (IR) light. Our study tests that hypothesis. Results suggest that potassium channel blockers disrupt the ability of IR to block propagating CAPs in Aplysia californica nerves, whereas sodium channel blockers appear to have no significant effect. These observations validate the modeling results and suggest potential applications of thermal block to many other unmyelinated axons.
Keywords
infrared inhibition, potassium channels, sodium channels, tetraethylammonium chloride, tetrodotoxin
Language
English
Publication Title
Neurophotonics
Grant
OT2 OD025307
Rights
© 2019 The Author(s). This is an Open Access work distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Mohit Ganguly, Jeremy B. Ford, Junqi Zhuo, Matthew T. McPheeters, Michael W. Jenkins, Hillel J. Chiel, E. Duco Jansen, "Voltage-gated potassium channels are critical for infrared inhibition of action potentials: an experimental study," Neurophoton. 6(4) 040501 (15 October 2019) https://doi.org/10.1117/1.NPh.6.4.040501
Manuscript Version
Final Publisher Version