Document Type
Article
Publication Date
1-1-1986
Abstract
This paper explores the possible sensory function of the identified histaminergic neuron C2. Mechanical stimulation of a narrow region around the mouth of the animal (perioral zone) elicits brief depolarizing potentials in C2. Extracellular recordings from the peripheral axons of C2 indicate that the depolarizing potentials are due to action potentials that are conveyed from the periphery but do not invade the cell body, since they fail at a region with a low safety factor within the cerebral ganglion. These blocked axonal spikes (A- spikes) function as if they were excitatory synaptic inputs to C2, since the synaptic output of C2 does not occur unless the A-spikes succeed in evoking full action potentials in the soma (or an electrically close initial segment) of C2. Furthermore, like synaptic potentials, the A-spikes exhibit temporal and spatial summation, and facilitation. C2 receives both tonic and phasic inhibitory synaptic potentials, which can decrease the summation of A-spikes and thereby alter the frequency-filtering properties of C2 or block its synaptic output. Thus, C2 appears to be an unusual proprioceptive afferent that has a high degree of integrative function and may provide critical gating that is dependent on a variety of external and internal conditions.
Language
English
Publication Title
Journal of Neuroscience
Grant
R37MH035564
Rights
© 1986 Society for Neuroscience. This work is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Recommended Citation
Weiss KR, Chiel HJ, Kupfermann I. Sensory function and gating of histaminergic neuron C2 in Aplysia. J Neurosci. 1986 Aug;6(8):2416-26. doi: 10.1523/JNEUROSCI.06-08-02416.1986. PMID: 3746415; PMCID: PMC6568747.
Manuscript Version
Final Publisher Version