Document Type
Article
Publication Date
2-20-2024
Abstract
Intracortical microelectrodes (IMEs) can be used to restore motor and sensory function as a part of brain–computer interfaces in individuals with neuromusculoskeletal disorders. However, the neuroinflammatory response to IMEs can result in their premature failure, leading to reduced therapeutic efficacy. Mechanically-adaptive, resveratrol-eluting (MARE) neural probes target two mechanisms believed to contribute to the neuroinflammatory response by reducing the mechanical mismatch between the brain tissue and device, as well as locally delivering an antioxidant therapeutic. To create the mechanically-adaptive substrate, a dispersion, casting, and evaporation method is used, followed by a microfabrication process to integrate functional recording electrodes on the material. Resveratrol release experiments were completed to generate a resveratrol release profile and demonstrated that the MARE probes are capable of long-term controlled release. Additionally, our results showed that resveratrol can be degraded by laser-micromachining, an important consideration for future device fabrication. Finally, the electrodes were shown to have a suitable impedance for single-unit neural recording and could record single units in vivo.
Keywords
microelectrode fabrication, neural interfaces, neuroinflammation, resveratrol
Publication Title
Journal of Micromechanics and Microengineering
Rights
© 2024 The Author(s). Published by IOP Publishing Ltd.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Natalie N Mueller et al. 2024. Effects of micromachining on anti-oxidant elution from a mechanically-adaptive polymer. J. Micromech. Microeng. 34 035009. DOI: 10.1088/1361-6439/ad27f7