Genetics and Genome Sciences Faculty, Staff, Student Scholarship
This collection holds the creative and scholarly works of the Department of Genetics and Genome Sciences' faculty, staff, and students. It includes scholarly content such as journal articles, book chapters, conference papers, etc.
Submissions from 2024
Examination of MGMT as a Risk Gene for Dementia in the Amish, Leighanne R. Main, Yeunjoo E. Song, Audrey Lynn, Renee A. Laux, Kristy L. Miskimen, Michael D. Osterman, Paula K. Ogrocki, Alan J. Lerner, M. Denise Fuzzell, Sarada L. Fuzzell, Sherri D. Hochstetler, and Jonathan L. Haines
Feasibility of a Low-Intensity Intervention to Influence Antibiotic Prescribing Rates Use in Outpatient Settings: A Cluster Randomized Controlled Clinical Trial, Brigid M. Wilson, Sunah Song, Robin L.P. Jump, and Federico Perez
Submissions from 2023
A Haptoglobin (HP) Structural Variant Alters the Effect of APOE Alleles on Alzheimer's Disease, Haimeng Bai, Penelope Benchek, Asha R. Kallianpur, Jonathan L. Haines, and William S. Bush
Inpatient Epidemiology, Healthcare Utilization, and Association with Comorbidities of Turner Syndrome: A National Inpatient Sample Study, Jirat Chenbhanich
Small Molecule Inhibitors of 15-PGDH Exploit a Physiologic Induced-Fit Closing System, Wei Huang, Hongyun Li, Janna G. Kiselar, Stephen P. Fink, Sagar Regmi, Alexander Day, Yiyuan Yuan, Mark R. Chance, Sanford D. Markowitz, and Derek J. Taylor
Prediction of Kinase-Substrate Associations Using The Functional Landscape of Kinases and Phosphorylation Sites, Serhan Yilmaz, Filipa Blasco Tavares Pereira Lopes, Mark R. Chance, and Mehmet Koyutürk
Submissions from 2022
Temporal and Sex-Linked Protein Expression Dynamics in a Familial Model of Alzheimer's Disease, Filipa Blasco Tavares Pereira Lopes, Daniela M. Schlatzer, Rihua Wang, Xiaolin Li, Emily Feng, Mehmet Koyutürk, Xin Qi, and Mark R. Chance
North American Genetic Counselors' Approach to Collecting and Using Ancestry in Clinical Practice, Alexandra Hubbel, Elizabeth Hogan, Anne Matthews, and Aaron Goldenberg
Investigation of a Cluster of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infections in a Hospital Administration Building, Lucas D. Jones, Ernest R. Chan, Sarah N. Redmond, Jeffrey D. Kovach, Marlin Linger, Peter A. Zimmerman, and Curtis J. Donskey
Obesity Accelerates Acute Promyelocytic Leukemia in Mice and Reduces Sex Differences in Latency and Penetrance, John W. R. Kincaid, Gretchen Weiss, Anne E. Hill-Baskin, Heidi M. Schmidt, Ovwoioise Omoijuanfo, Cheryl L. Thompson, Rose C. Beck, and Nathan A. Berger
Group B Streptococcus in the Urine in Nonpregnant Adults: Disease or Distraction?, Nicole Mongilardi, Brigid M. Wilson, Sunah Song, Robin L.P. Jump, and Federico Perez
Training the Next Generation of Translational Scientists: The Case Western Reserve University Translational Fellows Program, Cheryl L. Thompson, Tessianna A. Misko, and Mark R. Chance
Antibiotic Exposure and Acquisition of Antibiotic-Resistant Gram-Negative Bacteria among Outpatients at a US Veterans Affairs Medical Center, Brigid M. Wilson, Sunah Song, Federico Perez, and Robin L.P. Jump
Submissions from 2021
Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in a Patient Transport Van, Lucas D. Jones, Ernest R. Chan, Sarah N. Redmond, Jeffrey D. Kovach, Marlin Linger, Peter A. Zimmerman, and Curtis J. Donskey
Structurally Distinct External Solvent-Exposed Domains Drive Replication of Major Human Prions, Mohammad Khursheed Siddiqi, Chae Kim, Tracy Haldiman, Miroslava Kacirova, Benlian Wang, Jen Bohon, Mark R. Chance, Janna G. Kiselar, and Jiri G. Safar
Robust Inference of Kinase Activity Using Functional Networks, Serhan Yılmaz, Daniela M. Schlatzer, Mark R. Chance, and Mehmet Koyutürk
Molecular Diagnosis of SARS-CoV-2: Assessing and Interpreting Nucleic Acid and Antigen Tests, Peter A. Zimmerman, Christopher L. King, Mahmoud Ghannoum, Robert A. Bonomo, and Gary W. Procop
Submissions from 2020
Protein Footprinting: Auxiliary Engine to Power the Structural Biology Revolution, Mark R. Chance, Erik R. Farquhar, Sichun Yang, David T. Lodowski, and Janna G. Kiselar
Discovery of a Redox Thiol Switch: Implications for Cellular Energy Metabolism, Xing-Huang Gao, Jing Wu, Ilya Bederman, Zhaofeng Gao, Dawid Krokowski, Steven M. Chirieleison, Derek Abbott, Benlian Wang, Mark Cameron, Mark R. Chance, Belinda Willard, and Maria Hatzoglou
Inflammatory Pathway Analytes Predicting Rapid Cognitive Decline in MCI stage of Alzheimer’s disease, Jagan A. Pillai, Gurkan Bebek, Lynn M. Bekris, Aaron Bonner-Jackson, Stephen M. Rao, Mark R. Chance, and James B. Leverenz
Proteins Inform Survival-Based Differences in Patients with Glioblastoma, L. C. Stetson, Daniela M. Schlatzer, Peter Liao, Karen Devine, Kristin Waite, Marta E. Couce, Andrew E. Sloan, Mark R. Chance, and Jill S. Barnholtz-Sloan
Submissions from 2019
The XFP (17-BM) Beamline for X-ray Footprinting at NSLS-II, Awuri Asuru, Erik R. Farquhar, Michael Sullivan, Donald Abel, John Toomey, Mark R. Chance, and Jen Bohon
CoPhosK: A Method for Comprehensive Kinase Substrate Annotation Using Co-Phosphorylation Analysis, Marzieh Ayati, Danica D. Wiredja, Daniela M. Schlatzer, Sean Maxwell, Ming Li, Mehmet Koyutürk, and Mark R. Chance
Key Inflammatory Pathway Activations in the MCI Stage of Alzheimer’s disease, Jagan A. Pillai, Sean Maxwell, Lynn M. Bekris, Stephen M. Rao, Mark R. Chance, and James B. Leverenz
Submissions from 2018
Multidomain Architecture of Estrogen Receptor Reveals Interfacial Cross-Talk Between Its DNA-Binding and Ligand-Binding Domains, Wei Huang, Yi Peng, Janna G. Kiselar, Xuan Zhao, Aljawharah Albaqami, Daniel Mendez, Yinghua Chen, Hung-Ying Kao, Mark R. Chance, and Sichun Yang
Global Phosphoproteomics of CCR5-Tropic HIV-1 Signaling Reveals Reprogramming of Cellular Protein Production Pathways and Identifies P70-S6K1 and MK2 as HIV-Responsive Kinases Required for Optimal Infection of CD4+ T Cells, Danica D. Wiredja, Caroline O. Tabler, Daniela M. Schlatzer, Ming Li, Mark R. Chance, and John C. Tilton
Submissions from 2017
Proteomics and Network Analyses Reveal Inhibition of Akt-mTOR Signaling in CD4+ T Cells by Mycobacterium tuberculosis Mannose-Capped Lipoarabinomannan, Ahmad F. Karim, Obondo J. Sande, Sara E. Tomechko, Xuedong Ding, Ming Li, Sean Maxwell, Clifford V. Harding, Roxana E. Rojas, Mark R. Chance, and W. Henry Boom
Protein Footprinting Comes of Age: Mass Spectrometry for Biophysical Structure Assessment, Liwen Wang and Mark R. Chance
Structural Basis of Ligand Interaction with Atypical Chemokine Receptor 3, Liwen Wang, Sichun Yang, and Mark R. Chance
Submissions from 2016
Proteome and Protein Network Analyses of Memory T Cells Find Altered Translation and Cell Stress Signaling in Treated Human Immunodeficiency Virus Patients Exhibiting Poor CD4 Recovery, Sausan Azzam, Daniela M. Schlatzer, Sean Maxwell, Xiaolin Li, Douglas Bazdar, Yanwen Chen, Robert Asaad, Jill S. Barnholtz-Sloan, Mark R. Chance, and Scott F. Sieg
A Dynamical Systems Model of Progesterone Receptor Interactions with Inflammation in Human Parturition, Douglas Brubaker, Mark R. Chance, and Sam Mesiano
Submissions from 2015
MOBAS: Identification of Disease-Associated Protein Subnetworks Using Modularity-Based Scoring, Marzieh Ayati, Sinan Erten, Mark R. Chance, and Mehmet Koyutürk
Proteomics of Skin Proteins in Psoriasis: From Discovery and Verification in a Mouse Model to Confirmation in Humans, Kathleen C. Lundberg, Yi Fritz, Daniela Schlatzer, Giridharan Gokulrangan, Thomas S. McCormick, Mark R. Chance, and Nicole L. Ward
Apigenin Blocks IKKα Activation and Suppresses Prostate Cancer Progression, Sanjeev Shukla, Rajnee Kanwal, Eswar Shankar, Manish Datt, Mark R. Chance, Pingfu Fu, Gregory T. MacLennan, and Sanjay Gupta
Submissions from 2014
Integrating Phosphoproteomics in Systems Biology, Yu Liu and Mark R. Chance
Discovery of Common Sequences Absent in the Human Reference Genome Using Pooled Samples from Next Generation Sequencing, Yu Liu, Mehmet Koyutürk, Sean Maxwell, Min Xiang, Martina Veigl, Li Li, Thomas LaFramboise, Zhenghe Wang, Xiaofeng Zhu, and Mark R. Chance
Submissions from 2013
Structural Basis for the Oligomerization-State Switch from a Dimer to a Trimer of an Engineered Cortexillin-1 Coiled-Coil Variant, Saša Bjelić and Mark R. Chance
Phosphorylation of CDK9 at Ser175 Enhances HIV Transcription and is a Marker of Activated P-TEFb in CD4+ T Lymphocytes, Uri R. Mbonye, Giridharan Gokulrangan, Manish Datt, Curtis Dobrowolski, Maxwell Cooper, Mark R. Chance, and Jonathan Karn
Submissions from 2012
Identifying Stage-Specific Protein Subnetworks for Colorectal Cancer, Sinan Erten, Xiaowei Guan, Rod K. Nibbe, Jill S. Barnholtz-Sloan, Mark R. Chance, and Mehmet Koyutürk
MAGNET: MicroArray Gene Expression and Network Evaluation Toolkit, George C. Linderman, Mark R. Chance, and Gurkan Bebek
Gene Interaction Enrichment and Network Analysis to Identify Dysregulated Pathways and their Interactions in Complex Diseases, Yu Liu, Mehmet Koyutürk, Jill S. Barnholtz-Sloan, and Mark R. Chance
Gene, Pathway and Network Frameworks to Identify Epistatic Interactions of Single Nucleotide Polymorphisms Derived from GWAS Data, Yu Liu, Sean Maxwell, Tao Feng, Xiaofeng Zhu, Robert C. Elston, Mehmet Koyutürk, and Mark R. Chance
Novel Urinary Protein Biomarkers Predicting the Development of Microalbuminuria and Renal Function Decline in Type 1 Diabetes, Daniela Schlatzer, Mark R. Chance, Jean-Eudes Dazard, Xiaolin Li, and Fred Hazlett
Human Biomarker Discovery and Predictive Models for Disease Progression for Idiopathic Pneumonia Syndrome Following Allogeneic Stem Cell Transplantation, Daniela M. Schlatzer, Jean-Eudes Dazard, Rob M. Ewing, Serguei Ilchenko, Saada Eid, Mark R. Chance, and Kenneth R. Cooke
Submissions from 2011
Frontiers of Oncology: Biobanking Resources for the 21st Century, Jill Barnholtz-Sloan and Mark R. Chance
Submissions from 2010
An Integrative -omics Approach to Identify Functional Sub-Networks in Human Colorectal Cancer, Rod K. Nibbe, Mehmet Koyutürk, and Mark R. Chance
Prediction and testing of biological networks underlying intestinal cancer, Vishal N. Patel, Gurkan Bebek, and Mark R. Chance
Structural Characterization of HIV gp41 with the Membrane-proximal External Region, Wuxian Shi, Jen Bohon, and Mark R. Chance
Molecular Targets for Diabetes Mellitus-associated Erectile Dysfunction, Elizabeth Yohannes, Jinsook Chang, and Mark R. Chance
Submissions from 2009
Discovery and Scoring of Protein Interaction Subnetworks Discriminative of Late Stage Human Colon Cancer, Rod K. Nibbe, Sanford Markowitz, Lois Myeroff, Rob M. Ewing, and Mark R. Chance
Urinary Protein Profiles in a Rat Model for Diabetic Complications, Daniela M. Schlatzer, Jean-Eudes Dazard, Rob M. Ewing, Serguei Ilchenko, and Mark R. Chance
Target Selection and Annotation for the Structural Genomics of the Amidohydrolase and Enolase Superfamilies, Xiaojing Zheng and Mark R. Chance
Submissions from 2008
Proteomics Analysis Identifies Molecular Targets Related to Diabetes Mellitus-associated Bladder Dysfunction, Elizabeth Yohannes, Jinsook Chang, and Mark R. Chance
Submissions from 2005
Structural Allostery and Binding of the Transferrin·Receptor Complex, Guozhong Xu and Mark R. Chance
Submissions from 2004
DNA Binding Provides a Molecular Strap Activating the Adenovirus Proteinase, Mark R. Chance
Submissions from 2003
Structural Analysis of Gelsolin Using Synchrotron Protein Footprinting, Janna G. Kiselar and Mark R. Chance
Submissions from 1995
Purification of a Variant-specific Surface Protein of Giardia lamblia and Characterization of its Metal-binding Properties, Mark R. Chance
Submissions from 1993
Temperature Dependent Coordination Effects in Base-Off Adenosyl and Methylcobalamin by X-Ray Edge Spectroscopy, Mark R. Chance
Submissions from 1992
Formation of a Square-Planar Co(I) B12 Intermediate. Implications for Enzyme Catalysis, Mark R. Chance